Nos publications

Publications auxquelles ont participé des membres du  GFRS sur la sclérodermie systémique

Année 2017 ( En cours)

Controlling the digital ulcerative disease in systemic sclerosis is associated with improved hand function.
Mouthon L, Carpentier PH, Lok C, Clerson P, Gressin V, Hachulla E, Bérezné A, Diot E, Van Kien AK, Jego P, Agard C, Duval-Modeste AB, Sparsa A, Puzenat E, Richard MA; ECLIPSE study investigators..
Semin Arthritis Rheum. 2017 Jan 13. pii: S0049-0172(17)30036-7. doi: 10.1016/j.semarthrit.2017.01.001. [Epub ahead of print]


Treatment outcome in early diffuse cutaneous systemic sclerosis: the European SclerodermaObservational Study (ESOS).
Herrick AL, Pan X, Peytrignet S, Lunt M, Hesselstrand R, Mouthon L, Silman A, Brown E, Czirják L, Distler JH, Distler O, Fligelstone K, Gregory WJ, Ochiel R, Vonk M, Ancuţa C, Ong VH, Farge D, Hudson M, Matucci-Cerinic M, Balbir-Gurman A, Midtvedt Ø, Jordan AC, Jobanputra P, Stevens W, Moinzadeh P, Hall FC, Agard C, Anderson ME, Diot E, Madhok R, Akil M, Buch MH, Chung L, Damjanov N, Gunawardena H, Lanyon P, Ahmad Y, Chakravarty K, Jacobsen S, MacGregor AJ, McHugh N, Müller-Ladner U, Riemekasten G, Becker M, Roddy J, Carreira PE, Fauchais AL, Hachulla E, Hamilton J, İnanç M, McLaren JS, van Laar JM, Pathare S, Proudman S, Rudin A, Sahhar J, Coppere B, Serratrice C, Sheeran T, Veale DJ, Grange C, Trad GS, Denton CP.
Ann Rheum Dis. 2017 Feb 10. pii: annrheumdis-2016-210503. doi: 10.1136/annrheumdis-2016-210503. [Epub ahead of print]


Intravenous immunoglobulins in systemic sclerosis: Data from a French nationwide cohort of 46 patients and review of the literature.
Sanges S, Rivière S, Mekinian A, Martin T, Le Quellec A, Chatelus E, Lescoat A, Jego P, Cazalets C, Quéméneur T, Le Gouellec N, Senet P, Francès C, Deroux A, Imbert B, Fain O, Boukari L, Sené T, Deligny C, Mathian A, Agard C, Pugnet G, Speca S, Dubucquoi S, Hatron PY, Hachulla É, Launay D.
Autoimmun Rev. 2017 Apr;16(4):377-384. doi: 10.1016/j.autrev.2017.02.008. Epub 2017 Feb 13. Review.
PMID:28232167


CD16-positive circulating monocytes and fibrotic manifestations of systemic sclerosis.
Lescoat A, Lecureur V, Roussel M, Sunnaram BL, Ballerie A, Coiffier G, Jouneau S, Fardel O, Fest T, Jégo P.
Clin Rheumatol. 2017 Mar 14. doi: 10.1007/s10067-017-3597-6. [Epub ahead of print]
PMID:28293753


Silica-associated systemic sclerosis in 2017: 60 years after Erasmus, where do we stand?
Lescoat A, Cavalin C, Macchi O, Jégo P, Rosental PA.
Clin Rheumatol. 2017 Feb 17. doi: 10.1007/s10067-017-3576-y. [Epub ahead of print] No abstract available.
PMID:28213786


Vascular Evaluation of the Hand by Power Doppler Ultrasonography and New Predictive Markers of Ischemic Digital Ulcers in Systemic Sclerosis: Results of a Prospective Pilot Study.
Lescoat A, Coiffier G, Rouil A, Droitcourt C, Cazalets C, de Carlan M, Perdriger A, Jégo P.
Arthritis Care Res (Hoboken). 2017 Apr;69(4):543-551. doi: 10.1002/acr.22965. Epub 2017 Mar 3.
PMID:27390194


Systemic sclerosis and exposure to heavy metals: A case control study of 100 patients and 300 controls.
Marie I, Gehanno JF, Bubenheim M, Duval-Modeste AB, Joly P, Dominique S, Bravard P, Noël D, Cailleux AF, Benichou J, Levesque H, Goullé JP.
Autoimmun Rev. 2017 Mar;16(3):223-230. doi: 10.1016/j.autrev.2017.01.004. Epub 2017 Jan 27. Review.
PMID: 28137480


Long-term immune reconstitution and T cell repertoire analysis after autologous hematopoietic stem cell transplantation in systemic sclerosis patients.
Farge D, Arruda LC, Brigant F, Clave E, Douay C, Marjanovic Z, Deligny C, Maki G, Gluckman E, Toubert A, Moins-Teisserenc H.
J Hematol Oncol. 2017 Jan 19;10(1):21. doi: 10.1186/s13045-016-0388-5.
PMID:28103947


B Cell Homeostasis and Functional Properties Are Altered in an Hypochlorous Acid-Induced Murine Model of Systemic Sclerosis.
Sanges S, Jendoubi M, Kavian N, Hauspie C, Speca S, Crave JC, Guerrier T, Lefèvre G, Sobanski V, Savina A, Hachulla E, Hatron PY, Labalette M, Batteux F, Dubucquoi S, Launay D.
Front Immunol. 2017 Feb 7;8:53. doi: 10.3389/fimmu.2017.00053. eCollection 2017.
PMID: 28223983


Long-term follow-up after autologous adipose-derived stromal vascular fraction injection into fingers in systemic sclerosis patients.
Daumas A, Magalon J, Jouve E, Truillet R, Casanova D, Giraudo L, Veran J, Benyamine A, Dignat-George F, Magalon G, Sabatier F, Granel B.
Curr Res Transl Med. 2017 Jan – Mar;65(1):40-43. doi: 10.1016/j.retram.2016.10.006. Epub 2016 Nov 28.
PMID:28340695



Increased serum levels of fractalkine and mobilisation of CD34<sup>+</sup>CD45<sup>-</sup> endothelial progenitor cells in systemic sclerosis.

Benyamine A, Magalon J, Cointe S, Lacroix R, Arnaud L, Bardin N, Rossi P, Francès Y, Bernard-Guervilly F, Kaplanski G, Harlé JR, Weiller PJ, Berbis P, Braunstein D, Jouve E, Lesavre N, Couranjou F, Dignat-George F, Sabatier F, Paul P, Granel B.
Arthritis Res Ther. 2017 Mar 20;19(1):60. doi: 10.1186/s13075-017-1271-7.
PMID:28320472


Année 2016 :

Esophageal and anorectal involvement in systemic sclerosis: a systematic assessment with high resolution manometry.
Luciano L, Granel B, Bernit E, Harle JR, Baumstarck K, Grimaud JC, Bouvier M, Vitton V.
Clin Exp Rheumatol. 2016 Sep-Oct;34 Suppl 100(5):63-69. Epub 2016 May 24.
PMID:27243115


Does ex vivo CD34+ positive selection influence outcome after autologous hematopoietic stem cell transplantation in systemic sclerosis patients?
Oliveira MC, Labopin M, Henes J, Moore J, Papa ND, Cras A, Sakellari I, Schroers R, Scherer HU, Cuneo A, Kyrcz-Krzemien S, Daikeler T, Alexander T, Finke J, Badoglio M, Simões B, Snowden JA, Farge D.
Bone Marrow Transplant. 2016 Jun;51(6):889. doi: 10.1038/bmt.2016.126. No abstract available.
PMID:27245089


Lactose malabsorption in systemic sclerosis.
Marie I, Leroi AM, Gourcerol G, Levesque H, Menard JF, Ducrotte P.
Aliment Pharmacol Ther. 2016 Nov;44(10):1123-1133. doi: 10.1111/apt.13810. Epub 2016 Sep 28.
PMID:27677253


Nail involvement in systemic sclerosis.
Marie I, Gremain V, Nassermadji K, Richard L, Joly P, Menard JF, Levesque H.
J Am Acad Dermatol. 2016 Dec 20. pii: S0190-9622(16)31111-2. doi: 10.1016/j.jaad.2016.11.024. [Epub ahead of print]
PMID:28010889


A personalized physical therapy program or usual care for patients with systemic sclerosis: A randomized controlled trial.
Rannou F, Boutron I, Mouthon L, Sanchez K, Tiffreau V, Hachulla E, Thoumie P, Cabane J, Chatelus E, Sibilia J, Roren A, Berezne A, Baron G, Porcher R, Guillevin L, Ravaud P, Poiraudeau S.
Arthritis Care Res (Hoboken). 2016 Oct 1. doi: 10.1002/acr.23098. [Epub ahead of print]
PMID:27696703


Changes over Time and Responsiveness of the Cochin Hand Function Scale and Mouth Handicap in Systemic Sclerosis Scale in Patients with Systemic Sclerosis: A Prospective Observational Study.
Nguyen C, Bérezné A, Mestre-Stanislas C, Lefèvre-Colau MM, Rannou F, Guillevin L, Mouthon L, Poiraudeau S.
Am J Phys Med Rehabil. 2016 Dec;95(12):e189-e197.
PMID:27584140


Scleroderma peripheral B lymphocytes secrete interleukin-6 and TGF-β and activate fibroblasts.
Dumoitier N, Chaigne B, Régent A, Lofek S, Mhibik M, Dorfmüller P, Terrier B, London J, Bérezné A, Tamas N, Varin-Blank N, Mouthon L.
Arthritis Rheumatol. 2016 Dec 19. doi: 10.1002/art.40016. [Epub ahead of print]
PMID:27992693


Anti-Ephrin Type-B Receptor 2 (EphB2) and Anti-Three Prime Histone mRNA EXonuclease 1 (THEX1) Autoantibodies in Scleroderma and Lupus

Doua F. Azzouz 1,2 , Gabriel V. Martin 1,2 , Fanny Arnoux 1,2 , Nathalie Balandraud 1,3 , Thierry Martin 4,5 , Sylvain Dubucquoi 6,7 , Eric Hachulla 8 , Dominique Farge-Bancel 9,10 , Kiet Tiev 11 , Jean Cabane 11 , Nathalie Bardin 12 , Laurent Chiche 13,14 , Marielle Martin 1,2 , Eléonore C. Caillet 1,2 , Sami B. Kanaan 1,2 , Jean Robert Harlé 13 , Brigitte Granel 2,12,13 , Elisabeth Diot 15 , Jean Roudier 1,3 , Isabelle Auger 1,3 , Nathalie C. Lambert 1,2*

PLOS ONE | DOI:10.1371/journal.pone.0160283 September 12, 2016


 Evaluation of X Chromosome Inactivation with Respect to HLA Genetic Susceptibility in Rheumatoid Arthritis and Systemic Sclerosis

Sami B. Kanaan 1,2 , Onur E. Onat 3, Nathalie Balandraud 1,4 , Gabriel V. Martin1,2, J.Lee Nelson 5,6, Doua F. Azzouz 1,2, Isabelle Auger 1,2 , Fanny Arnoux1,2, Marielle Martin 1,2 ,Jean Roudier 1,2,4 , Tayfun Ozcelik 3 , Nathalie C. Lambert 1,2*

PLoS One. 2016 Jun 29;11(6):e0158550. doi: 10.1371/journal.pone.0158550. eCollection 2016


Efficacy of Autologous Microfat Graft on Facial Handicap in Systemic Sclerosis Patients.
Sautereau N, Daumas A, Truillet R, Jouve E, Magalon J, Veran J, Casanova D, Frances Y, Magalon G, Granel B.
Plast Reconstr Surg Glob Open. 2016 Mar 22;4(3):e660. doi: 10.1097/GOX.0000000000000621. eCollection 2016 Mar.
PMID:27257590


State of the art. Autologous fat graft and adipose tissue-derived stromal vascular fraction injection for hand therapy in systemic sclerosis patients.
Guillaume-Jugnot P, Daumas A, Magalon J, Sautereau N, Veran J, Magalon G, Sabatier F, Granel B.
Curr Res Transl Med. 2016 Jan-Mar;64(1):35-42. doi: 10.1016/j.retram.2016.01.006. Epub 2016 Mar 2.
PMID:27140597


Autologous adipose-derived stromal vascular fraction in patients with systemic sclerosis: 12-month follow-up.
Guillaume-Jugnot P, Daumas A, Magalon J, Jouve E, Nguyen PS, Truillet R, Mallet S, Casanova D, Giraudo L, Veran J, Dignat-George F, Sabatier F, Magalon G, Granel B.
Rheumatology (Oxford). 2016 Feb;55(2):301-6. doi: 10.1093/rheumatology/kev323. Epub 2015 Sep 8.
PMID:26350489


[Tolerance of bevacizumab therapy in systemic sclerosis-associated pulmonary arterial hypertension: A case report].

Sanges S, Desauw C, de Groote P, Fertin M, Lamblin N, Bervar JF, Hatron PY, Hachulla E, Launay D.
Rev Med Interne. 2016 Jun 28. pii: S0248-8663(16)30410-6. doi: 10.1016/j.revmed.2016.05.020. [Epub ahead of print] French.
PMID: 27370897


Special considerations in pregnant systemic sclerosis patients.
Sobanski V, Launay D, Depret S, Ducloy-Bouthors AS, Hachulla E.
Expert Rev Clin Immunol. 2016 Jun 8:1-13. [Epub ahead of print]
PMID: 27254104


Three cases of Jaccoud’s arthropathy during systemic sclerosis
Najm A, Le Goff B, Achille A, Espitia O, Durant C, Perrin F, Agard C.
Rev Med Interne. 2016 Feb 8. pii: S0248-8663(16)00036-9. doi: 10.1016/j.revmed.2016.01.007. [Epub ahead of print] French.
PMID: 26869295


Systemic sclerosis: Sexual dysfunction and lower urinary tract symptoms in 73 patients.
Sanchez K, Denys P, Giuliano F, Palazzo C, Bérezné A, Abid H, Rannou F, Poiraudeau S, Mouthon L.
Presse Med. 2016 Apr;45(4 Pt 1):e79-89. doi: 10.1016/j.lpm.2015.08.009. Epub 2016 Mar 23.
PMID: 27016850


Années 2014-2015:

Generalized calcinosis in systemic sclerosis.
Daumas A, Rossi P, Ariey-Bonnet D, Bernard F, Dussol B, Berbis P, Granel B.
QJM. 2014 Mar;107(3):219-21. doi: 10.1093/qjmed/hct195. Epub 2013 Sep 23. No abstract available.
PMID:24065835


Regenerative Approach to Scleroderma with Fat Grafting.
Magalon G, Daumas A, Sautereau N, Magalon J, Sabatier F, Granel B.
Clin Plast Surg. 2015 Jul;42(3):353-64, viii-ix. doi: 10.1016/j.cps.2015.03.009. Review.
PMID:26116941


[Is there a place of multiantigenes immunodot determination in systemic sclerosis patients without anti-centromeres or anti-Scl70 antibodies?].

Sautereau N, Gabsi A, Daumas A, Bardin N, Granel B.
Presse Med. 2015 May;44(5):547-9. doi: 10.1016/j.lpm.2015.01.004. Epub 2015 Mar 23. French. No abstract available.
PMID:25813097


Safety, tolerability and potential efficacy of injection of autologous adipose-derived stromal vascular fraction in the fingers of patients with systemic sclerosis: an open-label phase I trial.
Granel B, Daumas A, Jouve E, Harlé JR, Nguyen PS, Chabannon C, Colavolpe N, Reynier JC, Truillet R, Mallet S, Baiada A, Casanova D, Giraudo L, Arnaud L, Veran J, Sabatier F, Magalon G.
Ann Rheum Dis. 2015 Dec;74(12):2175-82. doi: 10.1136/annrheumdis-2014-205681. Epub 2014 Aug 11.


Prevalence of anti-RNA polymerase III antibodies in systemic sclerosis: New data from a French cohort and a systematic review and meta-analysis.

Sobanski V, Dauchet L, Lefèvre G, Lambert M, Morell-Dubois S, Sy T, Hachulla E, Hatron PY,Launay D, Dubucquoi S.
Arthritis Rheumatol. 2014 Feb;66(2):407-17. doi: 10.1002/art.38219. Review.
PMID: 24504813


Fructose Malabsorption in Systemic Sclerosis.
Marie I, Leroi AM, Gourcerol G, Levesque H, Ménard JF, Ducrotte P.
Medicine (Baltimore). 2015 Sep;94(39):e1601. doi: 10.1097/MD.0000000000001601.
PMID:26426642


Environmental risk factors of systemic sclerosis.
Marie I, Gehanno JF.
Semin Immunopathol. 2015 Sep;37(5):463-73. doi: 10.1007/s00281-015-0507-3. Epub 2015 Jul 4. Review.
PMID:26141606


Fecal calprotectin in systemic sclerosis and review of the literature.
Marie I, Leroi AM, Menard JF, Levesque H, Quillard M, Ducrotte P.
Autoimmun Rev. 2015 Jun;14(6):547-54. doi: 10.1016/j.autrev.2015.01.018. Epub 2015 Feb 4. Review.


Association of occupational exposure with features of systemic sclerosis.
Marie I, Menard JF, Duval-Modeste AB, Joly P, Dominique S, Bravard P, Noël D, Gehanno JF, Bubenheim M, Benichou J, Levesque H.
J Am Acad Dermatol. 2015 Mar;72(3):456-64. doi: 10.1016/j.jaad.2014.11.027. Epub 2015 Jan 10.


[CXCL4: a new biomarker of diagnosis and severity in systemic sclerosis?].
Marie I.
Rev Med Interne. 2015 Feb;36(2):69-72. doi: 10.1016/j.revmed.2014.10.007. Epub 2014 Nov 7. French. No abstract available.


Gastrointestinal mucosal abnormalities using videocapsule endoscopy in systemic sclerosis.
Marie I, Antonietti M, Houivet E, Hachulla E, Maunoury V, Bienvenu B, Viennot S, Smail A, Duhaut P, Dupas JL, Dominique S, Hatron PY, Levesque H, Benichou J, Ducrotté P.
Aliment Pharmacol Ther. 2014 Jul;40(2):189-99. doi: 10.1111/apt.12818. Epub 2014 Jun 2.


[Systemic sclerosis and occupational exposure: towards an extension of legal recognition as occupational disorder in 2014?].
Marie I.
Rev Med Interne. 2014 Oct;35(10):631-5. doi: 10.1016/j.revmed.2014.04.002. Epub 2014 May 10. French. No abstract available.


Prospective study to evaluate the association between systemic sclerosis and occupational exposure and review of the literature.
Marie I, Gehanno JF, Bubenheim M, Duval-Modeste AB, Joly P, Dominique S, Bravard P, Noël D, Cailleux AF, Weber J, Lagoutte P, Benichou J, Levesque H.
Autoimmun Rev. 2014 Feb;13(2):151-6. doi: 10.1016/j.autrev.2013.10.002. Epub 2013 Oct 12. Review.


Scleroderma Renal Crisis.
Guillevin L, Mouthon L.
Rheum Dis Clin North Am. 2015 Aug;41(3):475-88. doi: 10.1016/j.rdc.2015.04.008. Epub 2015 May 26. Review.
PMID: 26210130


Use of bosentan for digital ulcers related to systemic sclerosis: a real-life retrospective French study of 89 patients treated since specific approval.
Agard C, Carpentier PH, Mouthon L, Clerson P, Gressin V, Bérezné A, Diot E, Jego P, Lok C, Sparsa A, Chatelus E, Van Kien AK, Quéré I, Sibilia J, Hachulla E.
Scand J Rheumatol. 2014;43(5):398-402. doi: 10.3109/03009742.2014.887768. Epub 2014 Apr 11.
PMID: 24720440


Outcome of Patients with Systemic Sclerosis in the Intensive Care Unit.
Pène F, Hissem T, Bérezné A, Allanore Y, Geri G, Charpentier J, Avouac J, Guillevin L, Cariou A, Chiche JD, Mira JP, Mouthon L.
J Rheumatol. 2015 Aug;42(8):1406-12. doi: 10.3899/jrheum.141617. Epub 2015 Jul 1.
PMID: 26136487


The economic burden and health-related quality of life associated with systemic sclerosis in France.
Chevreul K, Brigham KB, Gandré C, Mouthon L; BURQOL-RD Research Network.
Scand J Rheumatol. 2015 May;44(3):238-46. doi: 10.3109/03009742.2014.976653. Epub 2014 Dec 18.
PMID: 25521915


Systemic sclerosis: views and thoughts for the future.
Mouthon L.
Presse Med. 2014 Oct;43(10 Pt 2):e265-6. doi: 10.1016/j.lpm.2014.08.003. Epub 2014 Sep 11. No abstract available.
PMID: 25220439


Pathophysiology of systemic sclerosis: state of the art in 2014.
Dumoitier N, Lofek S, Mouthon L.
Presse Med. 2014 Oct;43(10 Pt 2):e267-78. doi: 10.1016/j.lpm.2014.08.001. Epub 2014 Aug 29. Review.


[Pulmonary arterial hypertension associated with connective tissue diseases].
Legendre P, Mouthon L.
Presse Med. 2014 Sep;43(9):957-69. doi: 10.1016/j.lpm.2014.07.009. Epub 2014 Aug 14. Review. French.


Ischemic digital ulcers affect hand disability and pain in systemic sclerosis.
Mouthon L, Carpentier PH, Lok C, Clerson P, Gressin V, Hachulla E, Bérezné A, Diot E, Khau Van Kien A, Jego P, Agard C, Duval-Modeste AB, Sparsa A, Puzenat E, Richard MA; ECLIPSE Study Investigators.
J Rheumatol. 2014 Jul;41(7):1317-23. doi: 10.3899/jrheum.130900. Epub 2014 Jun 15.


Scleroderma renal crisis.
Mouthon L, Bussone G, Berezné A, Noël LH, Guillevin L.
J Rheumatol. 2014 Jun;41(6):1040-8. doi: 10.3899/jrheum.131210. Epub 2014 May 15. Review.


Clinical, functional and health-related quality of life correlates of clinically significant symptoms of anxiety and depression in patients with systemic sclerosis: a cross-sectional survey.
Nguyen C, Ranque B, Baubet T, Bérezné A, Mestre-Stanislas C, Rannou F, Papelard A, Morell-Dubois S, Revel M, Moro MR, Guillevin L, Poiraudeau S, Mouthon L; Groupe Français de Recherche sur la Sclérodermie.
PLoS One. 2014 Feb 28;9(2):e90484. doi: 10.1371/journal.pone.0090484. eCollection 2014.


Hand involvement in systemic sclerosis].
Mouthon L.
Presse Med. 2013 Dec;42(12):1616-26. doi: 10.1016/j.lpm.2013.10.003. Epub 2013 Nov 21. Review. French.


[Professional consequences of systemic sclerosis].
Bérezné A, Nguyen C, Mouthon L.
Presse Med. 2013 Sep;42(9 Pt 1):1159-70. doi: 10.1016/j.lpm.2013.04.011. Epub 2013 Aug 16. Review. French.


Telangiectasic mastocytosis with systemic sclerosis.
Frigui M, Dupin N, Carlotti A, Bussone G, Pestre V, Charles P, Crabol Y, Bérezné A, Guillevin L,Mouthon L.
Presse Med. 2013 May;42(5):902-4. doi: 10.1016/j.lpm.2012.10.014. Epub 2012 Dec 11. No abstract available.


Années 2012-2013:

Publications d’études cliniques:

Delayed gastric emptying determined using the 13C-octanoic acid breath test in patients withsystemic sclerosis.
Marie I, Gourcerol G, Leroi AM, Ménard JF, Levesque H, Ducrotté P.
Arthritis Rheum. 2012 Jul;64(7):2346-55. doi: 10.1002/art.34374.

Spontaneous intracranial hypotension syndrome in systemic sclerosis.
Marie I, Tollard E, Gerardin E, Guegan-Massardier E.
QJM. 2012 Feb;105(2):177-9. doi: 10.1093/qjmed/hcq243. Epub 2011 Jan 7. No abstract available.

1. Vanneaux V, Farge-Bancel D, Lecourt S, Baraut J, Cras A, Jean-Louis F, Brun C, Verrecchia F, Larghero J, Michel L. Expression of transforming growth factor β receptor II in mesenchymal stem cells from systemic sclerosis patients.BMJ Open. 2013 Jan 7;3(1). doi:pii: e001890. 10.1136/bmjopen-2012-001890. Print 2013.

2. Roustit M, Blaise S, Allanore Y, Carpentier PH, Caglayan E, Cracowski JL. Phosphodiesterase-5 inhibitors for the treatment of secondary Raynaud’s phenomenon: systematic review and meta-analysis of randomised trials. Ann Rheum Dis. 2013 Oct;72(10):1696-9.

3. Roustit M, Blaise S, Cracowski JL. Trials and tribulations of skin iontophoresis in therapeutics. Br J Clin Pharmacol. 2013 Apr 16. doi: 10.1111/bcp.12128. [Epub ahead of print] PubMed PMID: 23590287.

4. Kotzki S, Roustit M, Arnaud C, Boutonnat J, Blaise S, Godin-Ribuot D, Cracowski JL. Anodal iontophoresis of a soluble guanylate cyclase stimulator induces a sustained increase in skin blood flow in rats. J Pharmacol Exp Ther. 2013 Sep;346(3):424-31.

5. Interests and potentials of adipose tissue in scleroderma.Daumas A, Eraud J, Hautier A, Sabatier F, Magalon G, Granel B.Rev Med Interne. 2013 Sep 16. doi:pii: S0248-8663(13)00630-9.

Publications d’études Fondamentales:

2013:1. Kanaan SB, Azzouz DF, Balandraud N, Picard C, Auger I, Arnoux F, Martin M, Roudier J, Lambert NC.  Copy number variation of TLR7 and TLR8 genes is age and sex biased in peripheral blood cells. Soumis

2. Charpin C, Arnoux F, Martin M, Toussirot E, Lambert N, Balandraud N, Wendling D, Diot E, Roudier J, Auger I. New autoantibodies in early rheumatoid arthritis.Arthritis Res Ther. 2013 Jul 25;15(4):R78. [Epub ahead of print]

3. Picard C, Di Cristofaro J, Azzouz DF, Kanaan SB, Roudier J, Lambert NC. Analyzing HLA-G polymorphisms in children from women with scleroderma. Hum Immunol. 2013 Apr; 74(4):468-72. doi: 10.1016/j.humimm.2012.11.030. Epub 2012 Dec 8.

4. Wipff J, Dieudé P, Avouac J, Hachulla E, Cracowski JL, Diot E, Mouthon L, Sibila J, Tiev K, Meyer O, Kahan A, Boileau C, Allanore Y. Association study of CRP gene in systemic sclerosis in european caucasian population.. Rheumatol int 2013 Fev 9 ( Epub ahead of print).

 Generalized calcinosis in systemic sclerosis.Daumas A, Rossi P, Ariey-Bonnet D, Bernard F, Dussol B, Berbis P, Granel B. QJM. 2013 Oct 10. [Epub ahead of print] No abstract available.

 [Unusual cause of neck pain in systemic sclerosis]. Daumas A, Grob A, Faucher B, Melenotte C, Rossi P, Jean E, Frances Y, Granel B.  Rev Med Interne. 2013 Nov;34(11):719-20. doi: 10.1016/j.revmed.2013.08.010. Epub 2013 Sep 17.

  [Interests and potentials of adipose tissue in scleroderma.]Daumas A, Eraud J, Hautier A, Sabatier F, Magalon G, Granel B. Rev Med Interne. 2013 Sep 16. doi:pii: S0248-8663(13)00630-9. 10.1016/j.revmed.2013.08.007.

 Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry.  Guillevin L, Hunsche E, Denton CP, Krieg T, Schwierin B, Rosenberg D, Matucci-Cerinic M;    DUO Registry Group.Clin Exp Rheumatol. 2013 Mar-Apr;31(2 Suppl 76):71-80.

[Dyspnea and shortened phalanges.] Melenotte C, Rossi P, Reynaud Gaubert M, Harlé JR, Aissi K, Frances Y, Granel B.      Rev Med Interne. 2013 Apr 29. doi:pii: S0248-8663(13)00438-4. 10.1016/j.revmed.2013.03.328.

  Acute cerebral vasculopathy in systemic sclerosis.Faucher B, Granel B, Nicoli F.Rheumatol Int. 2012 Dec 23.

2012: 1- Baraut J, Farge D, Ivan-Grigore E, Verrecchia F, Michel L. Cytokines in Systemic Sclerosis : Focus on IL-17. Pathol Biol (Paris). 2012;60:127-39.

 2- Azzouz DF, Rak JM, Fajardy I, Allanore Y, Tiev KP, Farge-Bancel D, Martin M, Kanaan SB, Pagni PP, Hachulla E, Harlé JR, Didelot R, Granel B, Cabane J, Roudier J, Lambert NC. Comparing HLA Shared Epitopes in French Caucasian Patients with Scleroderma. PLoS One. 2012;7(5).

Sébastien Lepreux, Anne Solanilla, Julien Villeneuve, Joël Constans, Alexis Desmoulière and Jean Ripoche(2012). Blood Platelets and Systemic Sclerosis, Systemic Sclerosis – An Update on the Aberrant Immune System and Clinical Features, Dr Timothy Radstake (Ed.), ISBN: 978-953-307-869-4, InTech, Available from:

 

Années 2011:

Autologous HSCT in systemic sclerosis: a step forward. Farge D, Gluckman E.
Lancet 2011; 460-2.

Mood and anxiety disorders in systemic sclerosis patients. Baubet T, Ranque B, Taïeb O et al
Presse med 2011; 40: e 111-9.

Association of gender with clinical expression, quality of life, disability and depression and anxiety in patients with systemic sclerosis. Nguyen C, Bérezné A, Baubet T.
PLoS One 2011; e 17551.

Association of Fcy receptor IIIA variant with a subset of anti-topoisomerase I-positive patients in systemic’s pilot study. Magnant J, Ohresser M, Allanore Y et al.
Rheumatol Int 2011; 29: S6-9.

IgG from patients with pulmonary arterial hypertension and/or systemic sclerosis binds to vascular smooth muscle cells and induces cell contraction. Bussone G, Tamby MC, Calzas C et al.
Ann Rheum Dis 2011; Nov 14 (Epub ahead of print).

Targets of anti-endothelial cell antibodies in pulmonary hypertension and scleroderma. Dib H, Tamby MC, Bussone G et al.
Eur Respir J 2011; Oct 20. (Epub ahead of print).

Identification of target antigens of anti-endothelial cell and anti-vascular smooth muscle cell antibodies in patients with geant cell arteritis, a proteomic approach. Regent A, Dib H, Ly KH et al.
Arthrits Res Ther 2011; 13: R74.

Increased frequency of circulating Th 22 in addition to Th 17 and Th2 lymphocyts in systemic sclerosis: association with interstitial lung disease. Truchetet ME, Brambilla NC, Montanari E et al.
Arthritis Res Ther 2011; 13: R166.

A genetic variant located in the promoter region of the UPAR (CD 87) gene is associated with the vascular complications of systemic sclerosis. Manetti M, Allanore Y, Revillard l et al.
Arthritis Rheum 2011; 63: 247-56.

Années 2010:

Relationship between cytokine profiles and clinical outcomes in patients with systemic sclerosis. Baraut J, Michel L, Verrecchia F et al.
Autoimmun Rev 2010; 10: 65-73.

Association of the TNFAIP3 rs 5029939 variant with systemic sclerosis in the European Caucasian population. Dieudé P, Guedj M, Wipff J et al.
Ann Rheum Dis 2010; 69: 1958-64.

Antifibroblast antibodies from systemic sclerosis patients bind to (alpha)-enolase and are associated with interstitial lung disease. Terrier B, Tamby MC, Camoin L et al.
Ann Rheum Dis 2010; 69: 428-33.

Association of metalloprotease gene polymorphism and systemic sclerosis: a new perspective for the European Caucasian population. Wipff J, Dieudé P, Avouac J et al.
J Rheumatol 2010; 37: 599-602.

Oral sildenafil increases skin hyperaemia induced by ionophoresis of sodium nitroprusside in healthy volunteers. Blaise S, Hellmann M, Roustit M et al.
Br J Pharmacol 2010 ; 106 : 1128-34.

Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian population. Wipff J, Bonnet P, Ruiz B et al.
Rhumatol 2010; 37: 1164-7.

Increased alveolar concentration of nitric oxide is related to serum-induced lung fibroblast proliferation in patients with systemic sclerosis. Hua-Huy T, Tiev KP, Chereau C et al.
J Rheumatol 2010; 37: 1680-7.

Association of KCNAS gene polymorphism with systemic sclerosis –associated pulmonary arterial hypertension in the European Caucasian population. Wipff J, Dieudé P, Guegj M et al.
Arthritis Rheum 2010; 62: 3093-110.

Inactivation of the transcription factor STAT4 prevents inflammation-driven fibrosis in systemic sclerosis animals models. Avouac J, Fürnrohr BG, Tomcik M et al.
Arthritis Rheum 2010; Dec 15.

New onset of myasthenia gravis after treatment of systemic sclerosis autologous hematopoietic stem cell transplantation: sustained autoimmunity or inadequate reset of tolerance? Deligny C, Clave E, Sibon D et al.
Hum Immunol 2010; 363-5.

Dermal tissue and cellular expression of fibrillin 1 in diffuse cutaneous systemic sclerosis. Wipff J, Avouac J, Le Charpentier M et al.
Rheumatology 2010; 49: 657-61.

Années 2009:

The transport of high amounts of vascular endothelial grouth factor by blood platelets underlines their potential contribution in systemic sclerosis angiogenesis. Solanilla A, Villeneuve J, Auguste P.
Rheumatology 2009; 48: 1036-44.

Bank 1 is a genetic risk factor for diffuse cutaneous systemic sclerosis and has additive effects with IRF5 and STAT4. Dieudé P, Wipff J, Guedj M et al.

Arthritis Rheum 2009; 60: 3447-54.

STAT4 is a genetic risk factor for systemic sclerosis having effects with IRF5 on disease susceptibility and related pulmonary fibrosis. Dieudé P, Guedj M, Wipff J et al.
Arthritis Rheum 2009; 60: 2472-9.

Male microchimerism and HLA compatibility in French woman with scleroderma: a different profile in limited and diffuse subset. Rok JM, Pagni PP, Tiev K et al.
Rheumatology 2009; 48: 363-6.

Association between the IRF5 rs 2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis. Dieudé P, Guedj M, Wipff J et al.
Arthritis Rheum 2009; 60: 225-33.

A large multicenter analysis of CTGF-945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype. Rueda B, Simeon C, Husselstrand R et al.
Ann Rheum Dis 2009; 68: 1618-20.

Evidence of an antifibrotic affect of immunosuppressive drugs: applications in the treatment of systemic sclerosis. Verrecchia F, Wang Y, Vijo L.
Expert Rev Clin Immunol 2009; 5: 35-43.

Années 2008:

Angiogenesis in systemic sclerosis: impaired expression of vascular endothelial grouth factor receptor in endothelial progenitor-derived cells under hypoxic conditions. Avouac J, Wipff J, Goldman O et al.
Arthritis Rheum 2008; 58: 3350-61.

Circulating endothelial progenitor cells in systemic sclerosis: association with disease severity. Avouac J, Juin F, Wipff J et al.
Ann Rheul Dis 2008; 67: 1455-60.

Long-term follow-up results after autologous haematopietic stem cell transplantation for severe systemic sclerosis. Vank MC, Marjanovic Z, van den Hoogen GH et al.
Ann Rheum Dis 2008; 67: 98-104.

Therapeutic strategy combining intravenous cyclophosphamide followed by oral azathioprine to treat worsening interstitial lung disease associated with systemic sclerosis: a retrospective multicenter open label study. Bérezné A, Ranque B, Valeyre D.
J Rheumatol 2008; 35: 1064-72.

Polymorphic markers of fibrillin-1 gene and systemic sclerosis in European caucasion patients. Wipff J, Giraud M, Sibila J.
J Rheumatol 2008; 35: 643-9.

Identification of target antigens of antifibroblast antibodies in pulmonary arterial hypertension. Terrier B, Tamby mC, Camoin L et al.
Am J Resp Crit Care Med 2008; 15 : 1128-34.

The effect of imatinib (Glivec) on scleroderma and normal dermal fibroblasts: a preclinical study. Soria A, Cario-André M, Lepreux S et al.
Dermatology 2008; 216: 109-17.

Phenotypical and functional characteristics of in vivo expanded bone marrow mesenchymal stem cells from patients with systemic sclerosis. Larghero J, Farge D, Broccini A et al.
Ann Rheum Dis 2008; 67: 443-9.

Années 2007:

Immunoblotting on HEP-2 cells increases the detection of antitopoisomerase-1 antibodies in patients with systemic sclerosis. Tamby MC, Servettaz A, Guilpain P et al.
Clin Immunol 2007; 123: 82-8.

Antitopoisomerase-1 antibodies in systemic sclerosis: how to improve the detection? Tamby MC, Bussone G, Mouthon L et al.
Ann N Y Acad Sci 2007; 1109: 221-8.

Levels of circulating endothelial progenitor cells in systemic sclerosis. Allanore Y, Batteux F, Avouac J et al.
Clin Exp Rheumatol 2007; 25: 60-6.

Association between an endoglin gene polymorphism and systemic sclerosis-related pulmonary arterial hypertension. Wipff J, Kahan A, Hachulla E et al.
Rheumatology 2007; 46: 622-5.

Involvement of ERK signaling on halofuginone-driven inhibition of fibroblast ability to contract collagen lattices. Tacheau C, Michel L, Farge D et al.
Eur J Pharmacol 2007; 573: 65-9.

Années 2006:

IL13RA2 gene polymorphisms are associated with systemic sclerosis. Granel B, Allanore Y, Chevillard C et al.
Rheumatol 2006; 33: 2015-9.

Antibodies to fibroblasts in idiopathic and scleroderma-associated pulmonary hypertension. Tamby MC, Humbert M, Guilpain P et al.
Eur Respir J 2006; 28: 799-807.

Post-occlusive reactive hyperemia inversely correlates with urinary 15-F2t-isoprostane levels in systemic sclerosis. Cracowki JL, Kom GD,  Salvat-Melis M et al.
Free Radic Biol Med 2006; 40: 1732-7.

Evaluation of interleukin 13 polymorphisms in systemic sclerosis. Granel B, Chevillard C, Allanore Y.
Immunogenetics 2006; 58: 693-9.

Proteasone blockade exerts an antifibrotic activity by coordinately down-regulating type 1 collagen and tissue inhibitor of metalloprotease-1 and up-regulating metalloprotease-1 production in human dermal fibroblasts.  Fineschi S, Reith W, Guerne PA.
FASEB 2006; 20: 562-4.

Digital thermal hyperhemia impairment does not relate to skin fibrosis or macrovascular disease in systemic sclerosis. Salvat-Melis M, Carpentier Ph, Minson CT et al.
Rheumatology 2006; 45: 1590-6.

Modulation of collagen and MMP-1 gene expression in fibroblasts by the immunosuppressive drug rapamicin-A direct role as an antifibrotic agent? Pouldhon N, Farge D, Roos N.
J Biol Chem 2006; 281: 33045-52.

Transforming grouth-factor-beta signaling through the Smad proteins: role of systemic sclerosis. Verrecchia F, Mauviel A, Farge D et al.
Autoimmun Rev 2006; 5: 563-9.

Année 2005:

Tolerance and short term efficacy of rituximab in 43 patients with systemic autoimmune diseases. Gottemberg JE, Guillevin L, Lambotte O et al.
Ann Rheum Dis 2005; 64: 913-20.

Validation of French version of the Scleroderma Health Assessment Questionaire (SSc HAQ). Georges  C, Chassagny O, Mouthon L et al.
Clin Rheumatol 2005; 3-10.

Therapeutic intensification and autologous stem cell transplantation in autoimmune diseases. Marianovic Z, Gerber I, Toledano C et al.
Presse Med 2005; 34: 311-8.

Effects of short-time treatment with vitamin E in systemic sclerosis: a double blind, randomized controlled clinical trial of effect based on urinary isoprostane measurement. Cracowki JL, Girolet S, Imbert B et al
Free Radic Biol Med 2005; 38: 98-103.

Local hyperhemia to heating is impaired in secondary Raynaud phenomenon. Boignard A, Salvat-Melis M, Carpentier Ph.
Arthritis Res Ther 2005; 7: R1103-12.

Anti-endothelial cell antibodies in idiopathic and systemic sclerosis associated with pulmonary arterial hypertension. Tamby MC, Chanseaud Y, Humbert M et al.
Thorax 2005; 60: 765-72.

Année 2004:

Maitre A, Hours M, Bonneterre V et al. Systemic sclerosis and occupational risk factors: role of solvents and cleaning products.
J Rheumatol 2004; 31: 2395-401.

Nifedipine decreases sV CAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1. Allanore Y, Borderie O, Lemaréchal H et al.
Arthritis Res Ther 2004; 6: R309-14.

Acute and sustained effects of dihydropyridine-type calcium channel antagonists on oxidative stress in systemic sclerosis. Allanore Y, Borderie O, Lemaréchal H et al.
Am J Med 2004; 116: 595-600.

IgG reactivity with a 1000-kDA tissue and endothelial cell antigen identified as topoisomerase-1 distinguishes between limited and diffuse systemic sclerosis patients. Garcia de la Penä-Lefebvre P, Chanseaud Y, Tamby Mc et al.
Clin Immunol 2004; 111: 211-15.

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