Benjamin Terrier^1,2, Hervé Gouya³, Agnès Dechartres^4,5, Moncef Ben Arfi³, Alice Bérézne¹, Alexis Régent^1,2, Bertrand Dunogué^1,2, Jonathan London^1,2, Pascal Cohen¹, Loïc Guillevin^1,2, Claire Le Jeunne^1,2, Paul Legmann³, Olivier Vignaux³, Luc Mouthon^1,2

¹Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases of Ile de France, Hôpital Cochin, Assistance Publique–Hôpitaux de Paris (AP–HP), Paris; ²Paris Descartes University, Sorbonne Paris Cité, Paris; ³ Department of Radiology, Hôpital Cochin, AP–HP, Paris, France.

Abstract

Background. Myocardial microscopic fibrosis (MF) may occur during systemic sclerosis (SSc) and lead to impaired myocardial contraction and/or arrhythmia. Cardiac magnetic resonance imaging (MRI) is used for the noninvasive characterization of myocardium. The aim of this study is to evaluate the impact of CMRI with diffusion-weighted imaging (DWI) andT1 mapping sequences to assess perfusion defect and myocardial MF, respectively.